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2018;7(10):E298.doi:10.3390/jcm7100298 Bahramsoltani R, Rahimi R, FarzaeiMH

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Actomyosin contractility can compromise nuclear integrity by squeezing the nucleus dorsoventrally [191, 192], pulling it [193] or promoting the nuclear influx of cytoplasmic constituents, which in turn pressurizes the nucleus, leading to its rupture [155]

Common reasons patients explore this approach Patients often come in with a combination of concerns: Weight-loss frustration Difficulty losing weight Slow or stalled progress Weight regain Feeling stuck despite effort Appetite and behavior challenges Increased hunger Frequent cravings Difficulty feeling satisfied Inconsistent eating patterns Metabolic health concerns Insulin resistance concerns Blood sugar regulation Changes in body composition Weight-related health risks Long-term goals Better energy and consistency Improved confidence A more structured plan Sustainable progress What to expect We keep the process clear and guided from the start